Document 3207
 DOCN  M94A3207
 TI    Further studies on the ability of lithium (Li) to minimize the blood
       cell toxicity of AZT.
 DT    9412
 AU    Gallicchio VS; Kazini S; Townsley E; Hughes NK; Tse KF; Scott KF; Lin J;
       Birch NJ; Division of Hematology/Oncology, University of Kentucky,;
       Lexington 40536.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):129 (abstract no. PA0137). Unique
       Identifier : AIDSLINE ICA10/94369368
 AB    OBJECTIVE: To further investigate the capacity of Li to influence the
       hematopoietic toxicity of AZT. METHODS: Normal mice (C57BL/6) received
       dose-escalation AZT (0.1 and 2.5 mg/ml, i.p.) respectively for
       four-weeks with added Li2CO3 (1 mM). Li was stopped followed by a
       continuous 4-week period of AZT. Mice were evaluated on a weekly basis
       for their hematological toxicity by measurement of peripheral blood
       indices and progenitor cells from marrow and spleen for the eight-week
       study period. RESULTS: AZT induced dose-dependent toxicity that was
       measured by reduced indices and progenitor cells from marrow and spleen;
       however, in the AZT groups receiving Li, toxicity was reduced
       significantly (P value < 0.05) not only during the course of combined
       AZT and Li, but more importantly, the ability of Li to influence AZT
       toxicity carried over in the groups that had previously received Li and
       now had received only AZT compared to AZT controls.
       DISCUSSION/CONCLUSIONS: Use of Li provides an effective treatment to
       minimize AZT toxicity with lasting effects.
 DE    Animal  Bone Marrow/DRUG EFFECTS/PATHOLOGY  Dose-Response Relationship,
       Drug  Drug Administration Schedule  Hematopoietic Stem
       Cells/CYTOLOGY/DRUG EFFECTS/PATHOLOGY  Lithium Carbonate/*PHARMACOLOGY
       Mice  Mice, Inbred C57BL  Mitotic Index/DRUG EFFECTS  Spleen/DRUG
       EFFECTS/PATHOLOGY  Zidovudine/*TOXICITY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).